Solid-Phase Extraction (SPE)

Solid-phase extraction (SPE) is a technique for liquid-liquid extraction that is used to remove certain compounds from a mixture of impurities based on their physical and chemical properties. Analytical laboratories use SPE to concentrate and purify samples for analysis. SPE can be used to isolate analytes of interest from a wide variety of matrices, including urine, blood, beverage, and water samples. SPE requirements vary depending on the amount of sample required. SPE systems can be separated into large or small volume techniques. Large volume techniques generally use 100 mL or more of liquid sample.

The Mechanics of SPE

The Mechanics of SPE

The AutoTrace® 280 instrument performs automated solid-phase extractions (SPE) of large-volume liquid samples for organic analysis. Liquid-liquid extractions that normally take long hours can be automated using an AutoTrace SPE system (Ссылка). Extraction steps that normally require constant attention by chemists and technicians are performed automatically, and an AutoTrace instrument significantly reduces sample handling compared to techniques such as separatory funnel or vacuum manifold for SPE. The tedious and time-consuming steps of liquid-liquid extraction can be greatly decreased by automating the SPE steps of condition, load, rinse, and elute. AutoTrace systems offer a lower sample preparation cost-per-sample than other techniques by reducing solvent and labor cost by up to 90%.


AutoTraceExtractions for liquid sample sizes of 20 mL-20 L

  • Dramatic solvent reduction and reduced sample handling
  • Wide range of applications
  • Automation
  • Approved for use by many government agencies

See more about the AutoTrace® 280 instrument.