On-line analysis in IC

Integral™ systems provide a versatile and adaptable approach to on-line IC. An unsurpassed range of Reagent-Free™ IC (RFIC™) systems and IC capabilities can be combined with configurable sampling systems and adaptable off-the-shelf industrial enclosure options. Configure solutions for the process R&D lab, pilot plant, or production area. Focus engineering resources on implementation; not on instrumentation design.


Integral sampling modules and enclosures can be configured with ICS-5000 or ICS-2100 IC systems all with eluent generation capabilities and inert PEEK™ flow paths. Dual system solutions are available for increased throughput or complex analytical methods.

  • The Integral Migration Path approach to on-line implementation means systems can be configured for bench-top R&D studies, pilot plant remote wet-lab monitoring, or dedicated plant floor installations.
  • Versatile sampling and sample preparation capabilities provide support for system multiplexing and core functions such as dilutions, concentration, matrix elimination, and reagent addition.
  • Off-the-shelf enclosure options provide environmental protection and industrial compliance, when and where you need it.
  • Chromeleon® PA Process Analytical software provides system control, status, reporting, and connectivity with industrial control systems using industry standard OPC protocol.
  • Support for PAT systems is based on nearly 25 years of experience in a wide range of industries worldwide.

Typical analyzers are configured with one or more IC and RFIC systems, all analyzing the same sample in parallel. Each of these systems performs a specific IC or HPLC analysis.

An analyzer can be configured to handle from 1 to 21 sample streams. Sample streams are analyzed in series with the order and frequency determined by the user through software control.

Each system is configured with an appropriate analytical pump, detector, accessories, and set of analysis columns. These components are determined by the specific analysis being run on the system.

Integral sampling modules and enclosures

SP Sample Preparer

The Integral SP Sample Preparer provides versatile capabilities for sample preparation before chromatographic analysis. The SP is designed for continuous monitoring applications. Standard functions include sample and standard selection, preparation, and loading. Pressure, flow, and pH monitoring and dilution vessel heating are available options. The SP can be utilized with Dionex bench-top IC systems or within industrial systems configured with AE and LE enclosures.

SS Stream Selector

The Integral SS Stream Selector provides a full-featured module which automatically selects from up to 21 process streams for sequential analysis. The SS can be configured to deliver samples to up to four IC systems running in parallel. Sample streams can be configured to run to waste or sample recovery, deadhead at the SS valve, or recirculate back to the process.

Analyzer Enclosure (AE)

The Integral Analyzer Enclosure (AE) provides an adaptable housing for a variety of IC or HPLC system configurations. Stainless steel construction provides compatibility with harsh operating environment, as well as, the value of a long-lasting investment. The AE is designed for NEMA 12 / IP65 areas in its basic configuration. Options are available for configuring for NEC C1D2 / EU Zone 2 or NEC C1D1 / Zone 1 rated hazardous environments. Optional air conditioning allows operation in a wider range of environmental temperatures.

The AE can be wall mounted or installed on a LE Liquids Enclosure for a free-standing or wheeled unit. The AE also houses the PC-based controller, flat-panel display, and touch mouse device. Power input and automation connections are directed through the top of the AE. Liquid and gas connections are directed through the bottom and sides of the AE and LE.

LE Liquids Enclosure

The Integral LE Liquids Enclosure provides an optional base for the AE as well as a means of isolating and protecting eluent, reagent, and standards containers. It can also be used as an expansion enclosure for additional LC modules. The LE is designed to be NEMA 12 compliant, but can be configured for NEMA 4X / IEC IP56 operation.

Automation and Control

Dionex-designed Chromeleon PA software provides configuration, control, analyzer and system status, results display and trending, along with user-defined alarm actions and results reporting. All instrumentation is software controlled. All raw data is stored in a secure database with audit trail support. Multiple levels of security are available for access determined by the system administrator. For applications in the pharma/biopharma industry, Chromeleon PA meets the regulatory requirements of CFR 21, Part 11.

Process Analytical Market Solutions

Process Analytical systems from Dionex find applications in a wide range of industries and environments, offering the confidence of timely and trustworthy data, the advantages of knowledgeable process control, and the value of profitable process quality. Hundreds of Dionex on-line ICs and HPLCs are already in use worldwide; from process development laboratories to remote monitoring stations and manufacturing plant floors.


Use on-line HPLC systems for real-time determination of product quality in purification processes or determining reaction endpoint or impurity profiles in synthesis reactions. Use on-line Reagent-Free IC (RFIC) systems for monitoring nutrient levels such as amino acids, organic acids, and carbohydrates in fermentation reactors. Dionex offers a host of separation capabilities that are adaptable for on-line analysis.


On-line RFIC systems are used to monitor corrosion by-products in coolants and steam condensates, as well as make-up water quality. Systems are used in the nuclear power industry at PWR and BWR plants to monitor primary and secondary chemistries. Fossil fuel power plants find utility for migration systems in sampling labs, as well as on-line.


Process analytical RFIC systems are used to monitor ultrapure water and process chemicals. Key applications include part-per-trillion ion analysis in ultrapure water and determination of trace contaminants in semiconductor grade acids, bases, and solvents.


Analyzing environmental samples at the source, on-line RFIC and HPLC systems are used to determine naturally occurring species in river and delta waters, organic waste intermediates in industrial effluent processes, and toxics at hazardous materials remediation sites.


On-line RFIC and HPLC systems are used to determine concentrations of product in reactors and to monitor contaminants in process and waste streams.

Food and Beverage

Use HPLC and RFIC systems for real-time determination of product quality and product development processes. Process analytics can save time and improve quality for wide range of processes and products, including fermentation broths, purification steps, and other processes used to produce items such as dairy products, soft drinks, fruit juices, and bottled water.